Research Idiopathic hypersomnia

1 research

1.1 l-carnitine
1.2 levothyroxine
1.3 melatonin
1.4 hypocretin agonists

research
l-carnitine

abnormally low levels of acylcarnitine have been observed in patients narcolepsy. these same low levels have been associated primary hypersomnia in general in mouse studies. mice systemic carnitine deficiency exhibit higher frequency of fragmented wakefulness , rapid eye movement (rem) sleep, , reduced locomotor activity. administration of acetyl-l-carnitine shown improve these symptoms in mice. subsequent human trial found narcolepsy patients given l-carnitine spent less total time in daytime sleep patients given placebo.

levothyroxine

there have been studies suggesting levothyroxine possible treatment idiopathic hypersomnia, patients subclinical hypothyroidism. treatment carry potential risks (especially patients without hypothyroidism or subclinical hypothroidism), include cardiac arrhythmia.

melatonin

there have been few studies suggesting melatonin helpful in treatment of idiopathic hypersomnia. 1 small study used dose of 2 mg slow release melatonin @ bedtime , showed 50% of patients shortened nocturnal sleep duration, decreased sleep drunkenness , relieved daytime sleepiness.

hypocretin agonists

hypocretin-1 has been shown wake-promoting in animal models, not cross blood-brain barrier. suvorexant, hypocretin receptor antagonist, has been developed limit natural effects of hypocretin in patients insomnia. therefore possible hypocretin agonist may developed treatment of hypersomnia.