AT1 Angiotensin II receptor

1 at1

1.1 location within body
1.2 mechanism
1.3 effects

at1

the at1 receptor best elucidated angiotensin receptor.

location within body

the at1 subtype found in heart, blood vessels, kidney, adrenal cortex, lung , brain , mediates vasoconstrictor effects.

mechanism

the angiotensin receptor activated vasoconstricting peptide angiotensin ii. activated receptor in turn couples gq/11 , gi/o , activates phospholipase c , increases cytosolic ca concentrations, in turn triggers cellular responses such stimulation of protein kinase c. activated receptor inhibits adenylate cyclase , activates various tyrosine kinases.

effects

effects mediated at1 receptor include vasoconstriction, aldosterone synthesis , secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol , extracellular matrix formation.