Mechanism Na /K -ATPase

the sodium–potassium exchange pump.



the pump, after binding atp, binds 3 intracellular na+
ions.
atp hydrolyzed, leading phosphorylation of pump @ highly conserved aspartate residue , subsequent release of adp.
a conformational change in pump exposes na+
ions outside. phosphorylated form of pump has low affinity na+
ions, released.
the pump binds 2 extracellular k+
ions. causes dephosphorylation of pump, reverting previous conformational state, transporting k+
ions cell.
the unphosphorylated form of pump has higher affinity na+
ions k+
ions, 2 bound k+
ions released. atp binds, , process starts again.




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