Disease association HLA-DQB1

-



1 disease association

1.1 diabetes
1.2 celiac disease
1.3 multiple sclerosis
1.4 narcolepsy





disease association
diabetes

several alleles of hla-dqb1 associated increased risk of developing type 1 diabetes. locus has genetic name iddm1 highest genetic risk type 1 diabetes. again dqb1*0201 , dqb1*0302 alleles, particularly phenotype dqb1*0201/*0302 has high risk of late onset type 1 diabetes. risk partially shared hla-dr locus (dr3 , dr4 serotypes).


celiac disease

celiac1 genetic name dqb1, hla dqb1*0201, *0202, , *0302 encode genes mediate autoimmune coeliac disease. homozygotes of dqb1*0201 have higher risk of developing celiac disease, relative other genetic locus.


multiple sclerosis

certain hla-dqb1 alleles linked modest increased risk of multiple sclerosis.


narcolepsy

other hla-dqb1 alleles associated predisposition narcolepsy, hla-dqb1*0602, carried on 90% of patients narcolepsy-cataplexy.








Comments

Post a Comment

Popular posts from this blog

History Arab separatism in Khuzestan

-
1 history 1.1 shaykh khazal rebellion 1.2 further unrest (1920s–1940s) 1.3 after wwii 1.4 1979 uprising 1.5 asmla establishment 1.5.1 civil unrests 2005–15 1.6 sporadic insurgency , riots (2015–present) 1.6.1 2017 riots history shaykh khazal rebellion khuzestan has been troublesome province of iran since ascent of pahlavi rule in 1920s. in 2 decades before 1924, although nominally part of persian territory, western part of khuzestan functioned autonomous emirate known arabistan . eastern part of khuzestan governed bakhtiari khans because eastern part of khuzestan inhabited bakhtiari people. rising power of reza khan , increasingly negative attitudes on tribal autonomies in iran, tensions shaikh khazal of mohammerah had grown 1922 1924. attempts withdraw more taxes , reduce khazal s authority heated more. in response khaz al al-ka bi initiated rebellion. short rebellion sheikh khazal, @ peak in november 1924, crushed newly installed pahlavi dynasty minimal casualties. emirate dissolved
Read more

Cyberspace as an Internet metaphor Cyberspace

-
while cyberspace should not confused internet, term used refer objects , identities exist largely within communication network itself, website, example, might metaphorically said exist in cyberspace . according interpretation, events taking place on internet not happening in locations participants or servers physically located, in cyberspace . philosopher michel foucault used term heterotopias, describe such spaces simultaneously physical , mental. firstly, cyberspace describes flow of digital data through network of interconnected computers: @ once not real , since 1 not spatially locate tangible object, , real in effects. secondly, cyberspace site of computer-mediated communication (cmc), in online relationships , alternative forms of online identity enacted, raising important questions social psychology of internet use, relationship between online , offline forms of life , interaction, , relationship between real , virtual. cyberspace draws attention remediation of cultur
Read more

Discography Little Pattie

-
1 discography 1.1 albums 1.2 extended plays 1.3 singles discography releases little pattie unless otherwise indicated: albums the many moods of little pattie (1964) emi / hmv pattie (1965) emi / hmv little things (1965) emi / hmv the best of little pattie (1968) emi / columbia records beautiful in rain (1969) emi / columbia records i bring flowers (1972) ata / festival records pattie amphlett sunshine of life (1974) ata / festival records pattie amphlett only if want (1977) ata / festival records pattie amphlett 20 stompie wompie hits! (1981) emi moments (1995) labrava extended plays he s blonde headed real gone stompie wompie surfer boy (1963) emi / hmv little pattie (1964) pushin thing far (1965) emi / hmv dance puppet dance (1965) i ll eat hat (1967) emi / hmv singles
Read more